Wang et al. [74] found that chloroform extracts of agarwood prolonged the pain threshold induced by hot plate, and reduced the times of writhing reactions. Jinkoh-eremol and agarospirol may be the active compounds, and jinkoh-eremol’s analgesic effect could be blocked by naloxone (a opioid antagonist), whereas agarosporol was weakly effected by naloxone [51]. At the same time, jinkoh-eremol and agarospirol could inhibit D2 receptor binding and 5-HT2A receptor binding [51]. Additionally, compound 138 showed strong inhibitory activity in A23178- and antigen-induced degranulation assay, with IC50 values of 1.7 nM and 11 nM, respectively [41].
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