Product Safety & Toxicology

is a critical component of developing and commercializing agarwood-derived products such as essential oils, hydrosols, incense, and personal care formulations. Ensuring your products are non-toxic, safe for consumer use, and compliant with international regulations builds trust, protects public health, and supports market access globally.


1. What is Product Safety & Toxicology?

It involves scientifically evaluating whether a product—particularly those applied to skin or inhaled—is:

  • Free from harmful substances
  • Non-toxic in recommended doses
  • Safe for intended use (topical, inhalation, ingestion)

2. Key Safety & Toxicology Assessments for Agarwood Products

Test/AssessmentPurposeApplies to
GC-MS AnalysisIdentifies chemical compositionEssential oils
Dermal Irritation/Sensitization TestTests for skin reactionsOils, balms, cosmetics
Acute Oral Toxicity (LD50)Measures toxicity if ingestedRarely needed, but relevant for herbal/therapeutic use
Inhalation Toxicity TestFor incense or oil diffusersIncense, sprays
Microbial Load TestChecks for contaminationAll topical and ingestible products
Heavy Metal TestDetects lead, arsenic, mercury, etc.Products with plant residues or clay additives
Stability TestingShelf life and chemical changesEssential oils, cosmetics

3. International Safety Standards & Guidelines

Standard/BodyRelevance
IFRA (International Fragrance Association)Safety limits for essential oil components (e.g., safrole, eugenol)
REACH (EU)Chemical safety registration (especially for exports)
FDA (USA)Cosmetic labeling, toxicity, and safety requirements
ASEAN Cosmetic DirectiveSafety requirements for products in Southeast Asia
ISO 9235Defines “natural” aromatic raw materials
COSMOS/EcocertOrganic certification & safe formulation standards

4. Common Safety Concerns in Agarwood Products

IssueRiskSolution
High resin concentrationSkin sensitization or respiratory irritationDilute essential oils before application
Improper distillationContaminants or off-odorsUse food-grade stainless steel and clean water
Adulteration (e.g., synthetic oud)Unknown health effectsAuthenticate via GC-MS and maintain traceability
OverexposureInhalation sensitivity in enclosed spacesUse controlled dosages in diffusers or incense

5. Product Labeling Requirements

Include the following on your product packaging:

  • INCI names (e.g., Aquilaria malaccensis oil)
  • Usage instructions & warnings
  • Batch number and expiry date
  • Country of origin
  • Certification seals (if any)
  • Allergen disclosure (required in many markets)

6. Recommended Tests for Agarwood Oil (Oud Oil)

TestIdeal Range
GC-MS profile100% essential oil with identifiable marker compounds
Refractive index1.51–1.57
Specific gravity0.92–1.0
Acid value<5
Peroxide value<10 (fresh oils)
Sensory testingPleasant woody aroma without off-notes

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