Artificial Inducement or inoculation method is necessary for the Aquilaria Trees to develop agarwood.

The formation of agarwood is a result of a plant defense mechanism towards fungal attacks by producing resinous compounds as secondary metabolites. In their natural habitat, the process of resin accumulation as the result of tree-pathogen battle may take many years and the longer the process takes place the more expensive and highly valuable the resin is. Many scientists have been passionately trying to understand the cascade process of this tree-fungi interaction in producing agarwood. Isolation of various fungi from infected trees have been widely reported.

Using NOT suitable inoculants does not create the natural aroma in the development of resinous agarwood.